Take Very Good
Care of YouselvesDeuteronomy 4:15


style="mso-ansi-language: EN-AU" lang=EN-AU>face="Times New Roman">News in Science


lang=EN-AU>Lifestyle creating more type 1

style="FONT-SIZE: 12pt; mso-ansi-language: EN-AU" lang=EN-AU>face="Times New Roman">For a long time we are hearing about the link between
lifestyle and Type 2 diabetes.  Now
research is showing a growing link between lifestyle and Type 1

align=center>face="Times New Roman">

style="mso-ansi-language: EN-AU" lang=EN-AU>href="http://www.abc.net.au/reslib/200806/r257099_1064616.jpg">style="TEXT-DECORATION: none; text-underline: none">coordsize="21600,21600" o:spt="75" o:preferrelative="t"
path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">joinstyle="miter">eqn="if lineDrawn pixelLineWidth 0">eqn="sum 0 0 @1">eqn="prod @3 21600 pixelWidth">eqn="prod @3 21600 pixelHeight">eqn="prod @6 1 2">eqn="sum @8 21600 0">eqn="sum @10 21600 0">gradientshapeok="t" o:connecttype="rect">aspectratio="t">
style="WIDTH: 24pt; HEIGHT: 24pt" id=storyPhotosImg o:spid="_x0000_i1026"
type="#_x0000_t75" alt="cake and childs hand"
o:button="t">face="Times New Roman">

lang=EN-AU>Diet and lifestyle may be
playing a bigger role in the development of childhood type 1 diabetes
(Source: iStockphoto)

lang=EN-AU>A jump in the number of
'lower-risk' children being diagnosed with type 1 diabetes, has contributed to a
doubling in the number of cases over the past 20 years, say Australian

face="Times New Roman">Endocrinologist Dr Spiros Fourlanos from the href="http://www.mh.org.au/royal_melbourne_hospital/" target=_blank>face="Times New Roman">Royal Melbourne Hospitalface="Times New Roman"> and his colleagues report their findings in href="http://care.diabetesjournals.org/" target=_blank>face="Times New Roman">Diabetes Careface="Times New Roman">, which suggests environmental factors, such as sedentary
lifestyle, may be the cause.

style="mso-ansi-language: EN-AU" lang=EN-AU>Previous research has found the
incidence of children diagnosed with type 1 diabetes has doubled in
lang=EN-AU>Australiastyle="mso-ansi-language: EN-AU" lang=EN-AU> over the past two decades.

face="Times New Roman">In previous decades people with intermediate or low risk
human leukocyte antigen (HLA) genes were least likely to progress to diabetes in

face="Times New Roman">But the new study suggests a growing number of children
diagnosed with type 1 diabetes have intermediate risk HLA

face="Times New Roman">The study examined 462 Victorians who had been diagnosed
with childhood type 1 diabetes since 1950.

face="Times New Roman">Between 1950 and 1969, 79% of children diagnosed with
type 1 diabetes high risk HLA genes. In the period 2000 to 2005, this had
dropped to 28%. Simultaneously those with intermediate risk HLA genes jumped
from 20% to 48%, those with low risk genes remained stable at 3%.

style="mso-ansi-language: EN-AU" lang=EN-AU>"We found that surprisingly type 1
diabetes was starting to develop more often in the lower risk groups - occurring
increasingly in those with intermediate risk genes. Previously this was much
less common," co-researcher and
style="mso-ansi-language: EN-AU" lang=EN-AU>Royalstyle="mso-ansi-language: EN-AU" lang=EN-AU> style="mso-ansi-language: EN-AU"
style="mso-ansi-language: EN-AU" lang=EN-AU> style="mso-ansi-language: EN-AU"
style="mso-ansi-language: EN-AU" lang=EN-AU> director of diabetes and
endocrinology, Professor Peter Colman says.

face="Times New Roman">"High risk genes used to account for most cases but now
more are lower risk genes."


face="Times New Roman">Researchers believe environmental factors including
obesity, reduced exercise or vitamin D deficiency due to reduced sunlight
exposure, could be interacting with the HLA genes trigger childhood type 1

face="Times New Roman">Colman says that while the link between childhood obesity
and type 2 diabetes is well known, researchers now believe lifestyle factors may
also contribute to type 1 diabetes.


face="Times New Roman">He adds that the average age of children diagnosed with
type 1 diabetes with either immediate or low risk HLA genes, had decreased from
eight and half years old, to six years old.

face="Times New Roman">Colman cautions that "still only a small proportion of
those who have the HLA genes will develop type 1

face="Times New Roman">"However disease incidence and the ratio of intermediate
to high risk genes is continuing to increase so there is a much larger pool of
people with this genetic risk type, meaning a bigger possible pool of people who
can potentially develop diabetes," he says.

face="Times New Roman">Colman says 3% of first degree relatives (i.e. sisters
and brothers) of those diagnosed with type 1 diabetes will develop the disease.
As a result, an increasing number of siblings are being tested, in the hope new
future treatments such as intra-nasal and oral insulin, or gene therapy, could
prevent its progression.

style="mso-ansi-language: EN-AU" lang=EN-AU>face="Times New Roman">