Take Very Good
Care of YouselvesDeuteronomy 4:15






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Diabetes Drugs Januvia and Metformin

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class=MsoNormal>style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">Aprw:st="on">il 2, 2007 -- The FDA has approved Janumet, a new
drug for people with type 2 diabetes.

style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">Janumet is approved
for use in addition to diet and exercise for patients with type 2 diabetes whose
blood sugar is not adequately controlled by the diabetes drugs metformin or
Januvia.

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">Janumet is taken
orally twice daily with meals. It's
the first and only tablet that combines Januvia and metformin, notes Merck, the
drug company that makes Janumet and Januvia.

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">According to a Merck
news release, the FDA approved Janumet based on clinical data including Januvia
and metformin as separate tablets. Another study shows that Janumet is
equivalent to Januvia and metformin taken together, notes Merck.

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">Merck says it compared
Janumet to metformin in a six-month study of 701 people whose blood sugar was
mildly to moderately elevated,
despite taking metformin.

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">The patients were
assigned to take Janumet or to only take metformin during the
study.


style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">More than twice as
many patients taking Janumet got their hemoglobin A1c level (which indicates
blood sugar control over the previous six to 12 weeks) into the recommended
range, compared with those only taking metformin.

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">Patients taking
Janumet also lost 1.5
pounds
during the study, which is roughly the same amount
of weight lost by patients taking metformin alone (w:st="on" ProductID="1.3 pounds">1.3 pounds).

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">The risk of low blood
sugar (hypoglycemia), swelling, and gastrointestinal side effects was
similar in the Janumet and
metformin-only groups, according to Merck.

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">Janumet shouldn't be
taken by patients with conditions including liver disease, renal (kidney)
disease, renal dysfunction, type 1 diabetes, or a complication of diabetes
called diabetic ketoacidosis. 

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">Merck says Janumet
will be "broadly avaw:st="on">ilable in pharmacies in the near future." Merck is a
WebMD sponsor.

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style="FONT-FAMILY: Arial; COLOR: black; FONT-SIZE: 10pt">SOURCES: News release,
FDA. News release, Merck & Co.